Glossary

Creatine (Creatine Monohydrate)

Supplements Performance Muscle Building

Phosphocreatine booster for short, intense efforts (1–10 reps, sprints): faster ATP resynthesis, often +strength and a “fuller” look. Monohydrate is the gold standard. For hardgainers, it enables more training performance → better progression.

Notice

Notice

This page provides context and guardrails. It is not individual medical, nutrition, or training advice. Suitability and tolerance are individual; for pre-existing conditions, pregnancy/lactation, or medication, consult qualified professionals.

Definition & Mechanism

In short Creatine increases intramuscular phosphocreatine (PCr), which donates phosphate for rapid ATP resynthesis in the ATP/PCr system (0–10 s). Result: more reps at a given weight or more load for the same reps.

  • Main effects: +strength/+power, higher performance → indirectly more hypertrophy via SRA and progressive overload.
  • Cell hydration: mild increase in muscle water (“fuller look”), often +0.8–1.8 kg in early weeks.
  • Forms: Monohydrate remains the reference (bioavailability, cost, evidence). Other forms show no consistent added benefit.
Notice

Hypertrophy occurs via higher MPS and lower MPB with sufficient energy intake and protein; creatine is a performance multiplier, not a substitute.

Dosage (with or without loading)

Both reach the same intramuscular saturation; loading just achieves it faster.

ProtocolDoseDurationNotes
No loading3–5 g/day (monohydrate)continuousSaturation in ~3–4 weeks; well tolerated.
With loading~0.3 g/kg/day, split in 4 doses5–7 days, then 3–5 g/dayFaster effect; split doses/with meals if stomach-sensitive.
  • Body mass & training volume: heavier athletes/high volume → closer to 5 g/day.
  • Plant-based eaters: often benefit more (lower baseline stores).
  • Consistency > timing: time of day is secondary; with meals can improve tolerance. Consistency beats timing.

Intake & Practical Use (Hardgainer Guardrails)

  • Daily habit: 3–5 g monohydrate every day, ideally with a main meal.
  • Training effect: More output = manage RIR & RPE, progress load/reps, keep volume within MEVMRV.
  • Bulk synergy: Track weight via weekly averages and Rate of Gain (muscle + water). Expect +1–2 kg in the first weeks.

Safety & Side Effects

  • Healthy kidneys: 3–5 g/day is well tolerated in healthy individuals. If you have kidney/liver conditions, seek medical clearance.
  • Common: slight water/weight gain; occasional GI discomfort (splitting doses and taking with meals helps).
  • Myths: dehydration/cramps are not supported by evidence; adequate hydration is still wise.
Safety

On medication or with diagnosed conditions? Get clearance first. Stop and evaluate if adverse effects occur.

MYTH

“Creatine damages your kidneys.”

For healthy users at usual doses (3–5 g/day), evidence shows no renal harm. Get medical clearance if you have conditions or take medication. More context: Myth-Busting Series.

Note: Content is for orientation only; individual adjustments may be reasonable/necessary.

Notice

Notice

Descriptive information for orientation only — not therapy, diet, or training instructions. Consider individual differences and possible contraindications.

© Hardgainer Performance Nutrition® • Glossary • Updated: 27 Oct 2025